Andrew M. Wikenheiser
Post-doctoral fellow
NIDA Intramural Research Program
Baltimore, MD 21224 Lab website [link]
Google scholar profile [link]
Research interests
I am a systems neuroscientist interested in understanding how neural representations support behaviors like decision making. To investigate this question, I record the electrical activity of ensembles of neurons as rats are tested on carefully-designed behavioral tasks. I augment electrophysiology with optogenetic and chemogenetic techniques for manipulating neural activity, as well as computational analyses of neural and behavioral data. My future work will explore how the hippocampus and the orbitofrontal cortex interact during decision making, the encoding of spatial goals, and the formation of neural representations for abstract stimulus spaces.
In July 2018 I will be starting my lab as an assistant professor in the Department of Psychology at UCLA! I will be looking for post-docs, grad students, and technicians, so please contact me if you're interested in any of those positions.
Publications
Journal articles
Suppression of ventral hippocampal output impairs integrated orbitofrontal encoding of task structure AM Wikenheiser, Y Marrero-Garcia, G Schoenbaum
Neuron. 95(5), 1197–1207.e3. (2017)
[link] [.pdf]
Hippocampal theta sequences reflect current goals
AM Wikenheiser, AD Redish Nature Neuroscience. 18, 289–294. (2015)
Subjective costs drive overly-patient foraging strategies on an intertemporal foraging task AM Wikenheiser, DW Stephens, AD Redish PNAS. 110(20): 8308-8313. (2013)
The balance of forward and backward hippocampal sequences shifts across behavioral states AM Wikenheiser, AD Redish Hippocampus 23(1): 22-29. (2013)
Changes in reward contingency modulate the trial-to-trial variability of hippocampal place cells AM Wikenheiser, AD Redish J. Neurophysiology 106(2): 589-98. (2011)
KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation L Lin, W Sun, AM Wikenheiser, F Kung, DA Hoffman Molecular and Cellular Neuroscience 43(3): 315-25. (2010)
Protein kinase A mediates activity-dependent Kv4.2 channel trafficking RS Hammond, L Lin, MS Sidorov, AM Wikenheiser, DA Hoffman Journal of Neuroscience 28(30): 7513-7519. (2008)
Chapters, reviews, commentary, etc.
Rat mPFC and M2 play a waiting game (at different timescales)
AJ Langdon, AM Wikenheiser, G Schoenbaum Neuron 94(4): 700-702. (2017)
Towards a theoretical role for tonic norepinephrine in the orbitofrontal cortex in facilitating flexible learning
B Sadacca, AM Wikenheiser, G Schoenbaum
Neuroscience 345: 124-129. (2017)
[link] [.pdf]
Over the river, through the woods: cognitive maps in the hippocampus and orbitofrontal cortex AM Wikenheiser, G Schoenbaum Nature Reviews Neuroscience 17(8): 513-523. (2016)
The state of the orbitofrontal cortexMJ Sharpe, AM Wikenheiser, Y Niv, G Schoenbaum
Neuron 88(6): 1075-1077. (2015)
Decoding the cognitive map: ensemble hippocampal sequences and decision making AM Wikenheiser, AD Redish Current Opinion in Neurobiology 32: 8-15. (2015)
Hippocampal sequences and the cognitive map AM Wikenheiser, AD Redish A chapter in: Analysis and Modeling of Coordinated Multi-neuronal Activity Springer New York, 105-129. (2014)
Hippocampal sequences link past, present, and future AM Wikenheiser, AD Redish Trends in Cognitive Sciences 16(7): 361-362. (2012)
Dissertation
Hippocampal contributions to value-guided foraging |
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